ACTS 14:1 Now it happened in Iconium that they went together to the synagogue of the Jews, and so spoke that a great multitude both of the Jews and of the Greeks believed. 2 But the unbelieving Jews stirred up the Gentiles and poisoned their minds against the brethren. 3 Therefore they stayed there a long time, speaking boldly in the Lord, who was bearing witness to the word of His grace, granting signs and wonders to be done by their hands.
Anytime that you begin to speak to a group of people you will face some adversity. Evangelism always brings with it some distractions and disruptions. As Paul was speaking to large numbers of people there were some unbelievers that began poisoning the minds of Paul's hearers. I would imagine that this meant they would make up things that were not true to try and persuade others to stop listening to them. If you decide to go into any type of ministry endeavor, you can almost always expect opposition. How you deal with those disruptions will either make you or break you.
Paul did not pack up and leave the scene. He was not at all swayed to water down the gospel of to dial it down a notch. He spoke out all the more. He spoke boldly and you know what happened? God began backing him up with grace and some signs and wonders. Those naysayers began to see it! Irrefutable evidence that would support what Paul was saying. People may argue with what you say but they can never argue with what you do.
Today, just remember that when you feel like you are vulnerable and being isolated from the pack, God has got you covered. He will speak up for those that speak out for Him.